Mitochondria, Oxidants, and Aging

Mitochondria, Oxidants, and Aging

The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitocho...

Book: Aging and Oxidants in Animals and Plants Aging and oxidants in the nematode Caenorhabditis elegans

Mitochondria, obesity and aging

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Mitochondria and Aging

1Division of Biology of Aging, Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA 2Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, 25008 Lleida, Spain 3Mitochondrial Gerontology and Age-Related Diseases Group, Institute of Biomedical Technology and Tampere University Hos...

Mitochondria and the aging heart

The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual. Not surprisingly, advanced age is a major risk ...